Monthly Archives: February 2020

The Speed of Spread

I have opened my presentation slides on pandemics (nearly 400 slides) to find this small subset. This is a graphic representation of how quickly the Spanish Flu spread across the US in 1918 in just a few weeks. Remember, we didn’t have air travel at the time, so long distance travel was by train and recall that the Model T Ford had only come on the market in 1908, so travel by automobile was still relatively new. This is a good illustration of how quickly things can move through the US, but when you think about how much easier and quicker transportation is today, it’s likely things will spread much more rapidly.

The Rise of Three New Global Spread Centers

The global data has two things I’d like to point out. First, the case fatality rate seems to be stabilizing once again after a couple of weeks of steady climb. It will be interesting to see where it lands eventually, but I think 2.5-3.0% seems like a reasonable guess on my part.

Second, it’s pretty clear that we have a climbing incidence again. I will attribute this to China having done significant measures to control spread as well. as the number of cases climbing in Iran, Italy, and South Korea.

Also, remember not to compare these graphs directly to each other. The scales on them are different, although I’ve used the same time x-axis on all of them to help normalize a sense of what individual countries are contributing to the whole global case count.

An interesting feature in both the Iran and Italian data is the 100% fatality spike at the beginning of both outbreaks. This tells me that it is likely that they first identified cases in those countries either as the victims were either close to death or after their deaths. The other possibility is that they hadn’t reported cases initially.

It is still my feeling that Italy and South Korea will be better models of how things might unfold in the US, although both have flaws. South Korea has the benefit of the more acceptance of the common good over the individual as well as the impact of more common mask use by the public, which is a very good way to prevent the spread of respiratory droplets from those who are sick.

Italy is a bit more like our culture in the US, but they clearly made some mistakes about failing to handle their first cases correctly in a health care setting.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

The Role of Religion in Outbreaks

It’s time to discuss a couple of other global hot spots and want to focus on religious practices leading to the spread of disease.

South Korea is important because it is an economic and cultural bridge between East and West so it could easily act as a point of spread to other locations around the world.

The country has had only a handful of cases until mid-February. The sudden rise in cases is a good study in the need for social distancing. According to the South Korea Centers for Disease Control (KCDC), 339 out of 556 cases by Feb 23rd were linked to the Shincheonji Church of Jesus, the Temple of the Tabernacle of the Testimony. More cases were among a Catholic group of 39 people in the Andong Diocese who had traveled to the Holy Land. At the time of the KCDC report, 18 of the travelers had tested positive. By February 26, the number was closer to 30 of the travelers. 41 of the churches in the diocese had suspended mass and meetings until March 13th.

On Feb 26th, all 16 dioceses of the Catholic Church in South Korea had decided to suspend public mass, which affects 5.86 million members among 1747 churches and chapels. That has never been done in the church’s 236-year history in the country. Other denominational groups have begun to follow their lead.

The thing that I can’t determine is if they were incubating disease while in Israel. If so, this will be one of the important incidents in global spread because of the importance of Israel in world religion and as a destination for adherents from all parts of the world. It is pretty clear that if they were infectious during their time in the country that we can expect to see many more countries with cases in the next 2-4 weeks.

The situation in Iran is also very eye opening. The outbreak there likely started in Qom, which is one of the holy sites often visited by devout Muslims during the Hajj, which would start on July 28th. In an unprecedented move yesterday, the government of Saudi Arabia has closed all of the holy sites of Islam to foreigners, effectively bringing an end to any plans for the Hajj this year. This had not even been done during the Spanish Flu in 1918.

While that was a very good move on the part of the Saudis, it may be too late to help limit global spread from the Iranian epicenter. Researchers in Canada have modeled the epidemic in Iran using International Air Transport Association (IATA) data. Their conclusions are beyond alarming. “We estimated that 18,300 (95% confidence interval: 3770 –53,470) COVID-19 cases would have had to occur in Iran, assuming an outbreak duration of 1.5months in the country, in order to observe these three internationally exported cases reported at the time of writing…Given the low volumes of air travel to countries with identified cases of COVID-19 with origin in Iran (such as Canada), it is likely that Iran is currently experiencing a COVID-19 epidemic of significant size for such exportations to be occurring.

I think what can be extrapolated is that if their conclusions are correct, we can expect to see the disease emerging in countries with a high level of air travel to Iran. I’ve copied the table from the report showing the IATA data on air passenger travel from Iran.

A similar analysis was conducted in 2009 related to H1N1 influenza that had originated in Mexico. What was striking to me at the time was the strong correlation between where H1N1 was having large impact in US cities and the amount of air travel to those cities from Mexico.

I know the inevitable questions I’m going to be getting from people is “Should I travel to destination X?” I can clearly answer that question about some countries with a resolute “no,” but to be honest, at some point in the near future, I’m not sure that I would want to do any international travel, and that is coming from someone who loves to travel internationally. I’m not going to make a blanket statement. You need to assess your own acceptance of risk, but I hope you really think a lot about what is important to you as part of your decision.

Finally, I want to encourage everyone who reads this to share it with people in their churches, synagogues, mosques, temples, and other places of worship. Given that these locations are common community gathering spots, it is time to start having conversations about what steps your religious organizations are planning to take should this disease become common in your region.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

Something Positive

From February 27, 2020

I needed to find something to latch on for some hope, because frankly, looking at all this data and research is very depressing.

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Since China is the furthest along in this, I decided to look at the epidemic curve for the mainland. There is a little hope here. Clearly the number of new cases have dropped recently.

While this is positive, I also temper it with how different society is there than in the West, and I’ve alluded to that before. China as also taken very aggressive measures to control the spread, which might not be as accepted in other countries. Part of the reason for the spread in Italy was the failure to take the proper precautions at a hospital. I’m not surprised though. In my years of experience in hospital infection control, I’ve seen many shortcuts that would likely have produced the same result and have had to investigate the resulting outbreaks.

Coronavirus: inquiry opens into hospitals at centre of Italy outbreak

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

Why Italy is a New Level of Concern

From February 26, 2020

I will try to explain why my views of the impact of COVID-19 dramatically changed due to the cluster of cases in Italy. Of course, I’ll use a graph to try to make the concepts clearer.

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One of the terms we use in epidemiology is called the incubation period. That is the time from which a person is first exposed to a communicable disease until they start showing symptoms of the disease. They also can start spreading the disease later during this time period. I’ve represented that with three horizontal bars with gradients somewhat indicating that they get more likely to spread infection as they get closer to the time they are identified as a patient. The incubation period for this disease is thought to be 14 days, which is the lengths of the bars I used.

The first two cases (purple) were a husband and wife who were tourists from China. It is thought that he caused her illness as well as well as 12 others. There is only one other case (orange) that shows up on 2/7. No more are identified until 2/21, when over the course of five days we have seen an additional 319 cases so far. That is one of the things that is so alarming to me. There are three possibilities that I can think of:

1. There were other cases that haven’t been identified that spread the disease. This could be good or bad, depending on how much of a proportion of the population are asymptomatic spreaders.

2. These three individuals combined are somehow responsible for the next 319 cases (so far), or worse, maybe just 1 or 2 of them are. If this is the case, that means at a minimum that one person was responsible for over 100 cases, and if it’s only 1 or 2 of them causing most of the spread, a number much higher.

3. In some individuals, the incubation period may be longer than 14 days.

People like this are called super spreaders. For comparison, during SARS it is thought that the majority of the disease in Singapore was spread by five of these types of individuals, the highest causing 76 cases.

This is a concept I covered earlier called the reproductive number, or R0 of a disease. It’s the average people infected by an individual that is infected. The WHO estimate had been 1.4-2.5, but a recent analysis (link below) of various literature indicates that the value is 1.4 to 6.49 and with an average of 3.28. For comparison, the Spanish Flu of 1918 was 1.2-3.0

The reproductive number of COVID-19 is higher compared to SARS coronavirus

Combining this with what I had described earlier of the differences between how I expected this to travel in the West versus the East is very alarming. We are looking at a disease that could easily rival 1918 in scope. The mortality numbers I have calculated assuming a 30% attack rate (the percentage of the world population that get infected), which is the estimated rate from 1918, are simply shocking. However, we do not know exactly how many people will be infected, so this could be far worse or far better.

I’m sorry this one was probably a little more technical and harder to grasp but some concepts but it’s late and I don’t have the energy to wordsmith. I will try to answer any questions though as I have time.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

Not If, But When

From February 26, 2020

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I had been hopeful that COVID-19 could be contained because of some of the differences between eastern and western philosophies and social practices.. My update on Feb 24 had a change in tone. Now that we have almost 5 days of outbreak data in Italy, I am very concerned about the ramifications of this globally.

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This mirrors what was stated by Nancy Messonnier, the director of the CDC’s National Center for Immunization and Respiratory Diseases, “It’s not a question of if but rather a question of when and how many people will have severe illness.”

In short, start preparing. What transpires in Italy will be a good indicator of what will happen in other Western countries.

Please note that while the graphs of the diseases globally and in Italy use the same methodology, they have very different scales to represent the data. Don’t try to compare them to each other for that reason.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

Italian Alarm

From February 24, 2020

File:Flag of Italy (1946–2003).png - Wikimedia Commons

While the global picture continues to improve, I do have some concerns about COVID-19 at national levels. My biggest concern is the 215 cases in Italy.

One advantage of a strong central government in an outbreak situation is the ability to quickly enact policies to mitigate the spread of the virus. The rate at which hospitals were built in China was truly amazing as well.

Another reason I was a little less concerned about the disease in Asia is that respiratory hygiene measures such as mask use are now a part of the culture. This had started in Japan in 1918 during the Spanish Flu for obvious reasons, was reinforced by the Great Kanto Earthquake which led to a massive inferno in the city which resulted in smoke and ash that remained in the air for weeks. The influenza pandemic of 1934 further made mask use a common practice.

This was also spread by eastern medicine and philosophy, where “qi” is considered an essential element of health, which is tied to concepts of air, atmosphere, odor, etc. The use of masks quickly spread across eastern Asia for these reasons.

While eastern countries embrace the common good, in the west individualism and libertarian ideas make dealing with disease spread much more difficult. For example, think about how the antivax movement is causing a resurgence of measles in the US, which has been completely eliminated in 2000 as a result of vaccination efforts. Last year, there were 1282 cases in the US, which is a direct result of the antivax movement.

What people don’t seem to understand is that globally, measles has a case fatality rate of 15%, and about 0.2% in the US. In addition, about 25% of those infected with measles develop neurological damage.
https://www.cdc.gov/vaccin…/pubs/pinkbook/downloads/meas.pdf

The other point I will add on this topic is that herd immunity is crucial in preventing disease spread. Among those vaccinated for measles, about 10% do not develop adequate antibody protection, and thus are susceptible. Herd immunity protects both that group of the population as well as those who have true medical contraindications to the vaccine.

Hence, the West is likely less prepared to deal with a large cluster of cases in some countries because of these philosophical differences and resistance to some basic public health interventions.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

Don’t Use a Short Series of Data

From February 23, 2020

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New cases are back at a level yesterday that is more what I expected. It’s hard to say why there was the three days of considerably lower cased.

It’s also troubling that the case fatality rate has been slowly climbing.

This is a good example of why it’s never a good idea to rely on a very short series of data in a long stretch to identify trends.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

Climbing CFR

From February 21, 2020

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The good news is we had another day of low incidence of cases. That bad news is that the case fatality rate has been climbing. This could represent that those who have been ill that had not yet succumbed to their illness, In most people, the disease is the most severe on about day 7 of the onset of symptoms. For those that make it to day 11, they are on their way to recovery.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.

The Drop?

From February 20, 2020

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There’s a big drop in new cases today. I’m hopeful about that as well, but will want to see if this continues for a few more days. It could also be a gap in reporting like on 2/5 and 2/7.

Disclaimer: This commentary is my own interpretation and does not represent the analysis by the government or my employer. The data is from the Johns Hopkins University’s Center for Systems Science and Engineering.